Practice Name :
Dr. Antoine Sayegh
Description of Practice :
The new certificates of dr. Antoine Sayegh :
the special ( CV ) curriculum vitae
1 .in 1982 I got the certificate of MD ( medical doctor ). For 6 years with high marks especially in the last year of the studding in the faculty of medicine in Aleppo university and the faculty gave me many certificates :
1.special certificate in surgery because my marks were over 90/100 .
2.a gift certificate for particle experience in medicine from Yugoslavia in novi sad city from its hospital .
3.certificate for medical language of my high marks in its examinations .
4. certificate in the (6) last year as experience for my high marks in this year because I was the first student in this year .
2 . I study 3 years in Aleppo university for high education in internal medicine, I passed all examinations with high marks and I made the last examination in Damascus in ministry of health ,and I got the certificate in internal medicine in the 1986 the degree as master in internal medicine in the year 1983, I worked in homburg university in the department of hematology with prof .dr. Ernest Wenzel and in 1984 I worked in the cardiology department for the adults with prof .dr. Bette and I got many experiences in the part of the kinder Klink for congenital heart disease with pro .dr .dr .Fried. Carl. Sitzmann he gave many also experience certificates .
3 . I made many researches in my clinic and I got many certificates one from the minister of high education in the scientific week in the year 1992 of great honor and in the year 1995 I got a certificate from the minister of the health for 2 researches with the gift of Basel honor in the medical researches
4 . from the year 1987 to the year 1989 I teach in the Aleppo university in the medium medical institute for health: biochemistry, Anaestasia , nursery ,radiology and emergency cases
In the celebration after 25 years of the experiences in the works of the medical fields from Aleppo university from the faculty of medicine and I was one of the honored physicians
5.my addresses . clinic jabrrhei akhras street over the pharmacy artinian tel 00963 21 4657800
house . tajmil al jalla near moukhtarian school mardini building tel 00963 21 2333183 Aleppo Syria .
7. mobile 00963 955968573
8.my website :
Syria Blue Crescent Delegation FHM Medical Attache. H. E. Dr .Antoine Sayegh MD
9.My publications in the local journals
1.the arrhythmias in the patients with chronic obstructive lung diseases 1992 in the book 4 part 2 of the international scientific week the 32 in Damascus ( under direction of the high education minister).
2.practical study on VERPAMIL 40mg -80 mg in Syria 1995 in the local journal of the health ( under direction of the health minister ).
3.new indication of ( SYPHCOFLEX ) in the patients with the parietal chest pain 1995 in the local journal of the health ( under direction of the health minister ).
4.new treatment with nebulizer for inhaled ALBUTEROL 1997 in the local Syrian –Germany symposium in Damascus.
My last works and the activities :
1.the medical theories :
1.the dr. Antoine sayegh new theory in cancer.
2.the dr. Antoine sayegh new genetic constitutions.
3.the Symann syndrome ( the Sayegh-Sitzmann) Syndrome.
4.the interpretation of dr. Antoine sayegh for the proteasome mechanism.
5.the escape phenomena of the aids virus for the dr. Antoine sayegh.
6.the interpretation of the secret of the live and the death from the dr. Antoine Sayegh
7. The newest dr. Antoine Sayegh declarations on the cancer treatments and for the aids also :
The newest relations between the Calcium channels blockers (CCB) and the angiotensin converting enzyme inhibitors (ACEI) with the transcription factor nuclear factor E2-related factor 2 (Nrf2) directly or indirectly as anti oxidant or anti cancer
On the websites :
8. The new dr. Antoine Sayegh methods for treatments from the stem cells:
9.many theoretic researches in the treatments for the aids ,for the cancer ,and for the genetic diseases .
10. DR. Antoine Sayegh experiments in cancer:
2. the international medical participations in :
1. the telephone work shop for cancers from the international (Cancer Care) .
2.the webinar for the international genetic engineering biotechnology .GEN webinar, Science Careers webinar, ALT webinar, AAA webinar
3. the international campaigns against cancer with livestrong.
4.many invitations to participate in the international conferences for the aids ,the cancers ,and for the genetic diseases from many countries of the world.
5.many nominations for an international awards from many cancer centers especially from my nomination from my pro .dr. F. C. Sitzmann for Albert Szent Gyrgyi awards from NFCR.
3.my other international participations : as a member or colleague ,or registered member:
1.with many offices of the united nations .as example :
a. the office of Genève (UNOG).
b. the global reporting initiative (GRI).
c. the security council report
c. the united nation global compact.
d. united nation Environment program (UNEP).
e. the united nation human development report(UNDP).
f. My global fund.
g. ESCKWA,UN news ,UN wire
h. international court of justice.
i. international criminal court .
j. world health organization(WHO).
k. icgeb. UN aids. UN general assembly ,UN the regional of Europe
l. united nations Galaxy e-staffing system.
m. united nations office drug and crime (UNODC).
n. united nations headquarters in New York.
o. office of the United Nations High Commissioner for Human Rights (OHCHR) Civil Society
p. member of the international human rights commission and IHRC headquarter and member of l’Organisation Mondiale Contre la Torture (OMCT).
r. member of the group of the international human rights organization
s. many other offices of the united nations .
2.with many organizations for the human rights . as examples :
a. Amnesty international.
b. physician for human rights.(PHR)
c. international physician for prevention nuclear wars (IPPNW).
d. green peace .
e. human rights watch (HRW).
f. international justice mission.
g. the global climate .
h. many other human rights organizations.
3.with many international research centers for aids ,for cancer ,and for genetic disorders : as example :
a. IUSTI.( the international union against sexually transmitted infections)
b. international union against cancer (UICC).
c. American cancer society. American association for cancer research
d. center for disease control and prevention (CDC).
e. iarc ( international agency for research on cancer )
f. science AAA ( American association for the advancement of science ) .
g. FP7 program of the European commission .
h. ESGCT( the European society of gene and cell therapy) .
i. technology strategy board.
g. European association for cancer research (EACR).
K. national foundation for cancer research(NFCR).
L. national cancer institute (NCI).
m. proposal CENTRAL application system.
n. association for international cancer research (aicr).
o. Saarland university .
p. National Human Genome Research Institute.
r. NIH ,NIAID,NHLBI, Canadian institute of health research, ISREC, Nobel prize foundation, Marie curie foundation, INSTITUTE CURIE.
s. many other medical research centers .
4.in my country Syria :
- I am a member in the scientific committee of the Aleppo department of the Syrian medical association .
- I am a member of the SADU ( the Syrian graduates from German universities )
5.the international association of internists recognized me as
THE LEADING PHYSICIAN OF THE WORLD
6. Ambassador of the Syrian blue crescent
With the best regards from:
Ambassador .H . E. Dr .Antoine Sayegh MD
Syria Blue Crescent Society
Director / Delegate FHM Medical Attaché.
Faculty of Humanitarian Medics (FHM)
Director for Syrian Human Rights Council(SHRC)
The strongest international defender of the world for human rights
Syria Blue Crescent Delegation FHM Medical Attache. H. E. Dr .Antoine Sayegh MD .
My new E-mails:
Areas of Expertise :
for 24 years
Honors and Awards :
- certificates one from the minister of high education in the scientific week in the year 1992 of great honor
- certificate from the minister of the health for 2 researches with the gift of Basel honor in the medical researches
Teaching and Speaking :
in my cv
Research Interests :
The newest dr. Antoine Sayegh declarations on the cancer treatments and for the aids also : http://sayeghresearches.wetpaint.com/ My great dear: please contact me on these E-mails in the same time to confirm your sending of your e-mails to me E-mails: firstname.lastname@example.org email@example.com firstname.lastname@example.org email@example.com the websites :http//:sayeghresearches.wetpaint.com http//:antsay.webs.comwith the best regards from the dr. Antoine SayeghThe newest dr. Antoine Sayegh declarations on the cancer treatments and aids also :I call all the cancer research centers of the world to concentrate on my new suggestions in their trials on cancer and on aids also : We must use the combinations from many drugs which act on the ( Myristate , farensyl ,glucosylphosphatidylinositol ) in the same time in the protection from cancers which promise us for the new the treatments for the aids and the cancer also. The membrane-attached proteins divided into three groups: 1.group A : bound to the cytosolic face of the plasma membrane by myristate as v-Src is a kind of non-receptor protein tyrosine kinase involved in cell signaling: 1.we must get more benefits from the properties of the Dihydropyridine-type calcium-channel antagonists (DTCCA) which plays an important roles in many diseases , because they decrease vasospastic propensity. These drugs are suspected to have anti-oxidant properties in other diseases as in the systemic sclerosis . that nifedipine and nicardipine decrease circulating markers of oxidative stress damage in patients.. the effects of nifedipine on O2•- release from human monocytes, on protein phosphorylation with phorbol myristate acetate (PMA) as stimulator and on protein kinase C (PKC) activity, This beneficial property of nifedipine seems to be mediated by its cellular action and by the inhibition of PKC activity,so we can use this drugs against the diseases which associate with the oxidative harms. ( Paris V University, Cochin Hospital, Cochin Institute,france) 2.we must get more benefits also from the relations from the Phorbol 12-Myristate 13-acetate (PMA) and angiotensin II (Ang II)which increased both the percentage of scavenger receptors Scr-positive cells and the Scr mean fluorescence intensity. PMA and Ang II also increased Scr mRNA and promoter activity in a time- and dose-responsive manner. Protein kinase C and calmodulin transduction pathways were involved in Scr up-regulation induced by PMA and Ang II. Additionally, a serine/threonine kinase was involved in PMA stimulation. Functional analysis showed that both AP-1 and ets motifs were specific response elements to PMA stimulation in HMCLs ,so the drugs which change the relations between the PMA and the ANGII which inhibits the actions of the ANGII can breaks down the transduction pathways (Center for Nephrology, Royal Free and University College Medical School, Royal Free Campus, London, England, United Kingdom) 2. group B:bound to the cytosolic face of the plasma membrane by farnesyl as Ras protein which also plays a key role in cell signaling: From my participation with Webinar on the antitumor effects of the biophosphonate in breast cancer 1. The gene on the chromosome 1 and the location q22 encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, a substrate for protein farnesylation and geranylgeranylation, Drugs Zoledronic acid is an amino-bisphosphonate that inhibit this enzyme FPP [farnesyl diphosphate] synthase prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene .so we can can the Bisphosphonates as clodronate and zoledronic acid to inhibit also the other isoforms . 2.the second point to avoid the the harm effects on the normal cells from the uses of the Bisphosphonates as clodronate and zoledronic acid , we can use the antibodies against the FPP [farnesyl diphosphate] synthase as in my theoretic researches for temporary periods instead of the biophosphonates Please visit the all researches I and all researches II on my website http://sayeghresearches.wetpaint.com/ http://sayeghresearches.wetpaint.com/forum 3.from the effects of the uses of the biophosphonates on the relation the FPP [farnesyl diphosphate] synthase as a molecular partner for p13(II) and G4 accessory proteins which opens new prospects for treatment of retrovirus-induced leukemia HTLV1 p13(II) not on cancer but on the retroviruses also 4, the HMG-CoA reductase inhibitors (statins) as an anticancer drugs: from the international researches we found : ( University of Mainz, Germany ) Apart from their lipid lowering activity, HMG-CoA reductase inhibitors (statins) impair numerous cellular functions associated with metastasis, e.g. gene expression, angiogenesis, cell adhesion, cell motility and invasiveness. Furthermore, statins have impact on apoptotic cell death and modulate cellular susceptibility to cell killing by anticancer drugs and ionizing radiation. Part of the effects provoked by statins are due to the inhibition of the prenylation of low molecular weight GTPases, in particular Ras and Rho, which play key roles in signaling evoked by stimulation of cell surface receptors. C-terminal lipid modification of Ras/Rho GTPases is essential for their correct intracellular localization and function. By depletion of the cellular pool of isoprene precursor molecules, statins reduce the level of membrane-bound active Ras/Rho proteins, thereby impairing corresponding functions. Since broad clinical experience already exists for statins, their incorporation into established tumor-therapeutic regimens would be realizable in a rather short period of time. Here, data available at present arguing for the usefulness of statins in anticancer therapy are summarized and discussed. 3. group C: bound to the extracelluar face of the plasma membrane by glycosylphosphatidylinositol;(dr. Antoine Sayegh clinic Aleppo ,Syria) 1.the amlodipine acts as Calcium channels blockers (CCB) which inhibits for the CA++ to enter intracellular from many mechanisms by the blocking the voltage channels dependent for the CA++ or from the acting on the receptor channels dependent for CA++ ,and from the other actions of the CCB on the relations between the CA++ and the IP3 which plays an important roles on its formation from the PIP2 to IP3 + DAG and on its receptors ( ip3)also from the effects of the CA++ on the ubiquitin proteasome pathway ,so from the last roles of the CCB which inhibits the actions of the CA++ on the relations between the CA++ and the IP3 and on the also IP3 receptors So we can we use the CCB for the treatment for the cancers ,because the IP3 and the CA++ with the relation with the calcineurin and the active NFAT help for the genes transcription , so ,we must study the patients which treated from the CCB and we must evaluate the ratios of the cancers in these groups of the patients ( the ratios in this group very very low ) ,also from the roles of the multiple kinase as the(calcium/calmodulin-dependent protein kinase (CaMK),with the other proteinkinase as protein kinase D (PKD), microtubule affinity-regulating kinase (MARK), salt-inducible kinase (SIK), checkpoint kinase-1 (CHK1) and other kinases) mediate specific phosphorylation of human histone deacetylase-4 (HDAC4) on three 14-3-3-binding sites. Myosin phosphatase-targeting subunit-1 (MYPT1)–protein phosphatase-1 (PP1) and PP2A can also act on these sites. The association of 14-3-3 proteins with HDAC4 retains it in the cytoplasm and prevents its interaction with transcription factors such as myocyte enhancer factor-2 (MEF2), thereby releasing these transcription factors for transcriptional activation. So when we inhibits the (calcium/calmodulin-dependent protein kinase (CaMK)which acts with other mechanisms in the signaling of the CA++ for the translations and for the transductions or transcription on the genes by the STAT or SMAD4 pathways2. we use the angiotensin converting enzyme inhibitors (ACEI) with the CCB so to get the most important synergistic effects from their combination , and because the ACEI inhibits the actions of the Ang II ,and from the relation from the Ang II on the ATII receptor and on the ATI receptor especially also ( angiotensin I receptor) which excite the formation of the IP3 also from the PLC which acts to form the IP3 and the DAG from the PIP2,so the IP3+ the CA++ and the DAG activates the PKC which play as the vasoconstrictive roles in the hypertension ( HT) , so when we use the combination from the ACEI +CCB we get the best effects on the HT from the vasodilatation roles and from the indirect effects on the IP3 formation, so we can use the ACEI + CCB in the treatment of the cancer in the futures also .3.the most important notices for the treatments for the cancer from two new ways : a. the neprilysin path ways :(from the mechanism of degradation ) which convert the GTP to c GMP with the CA++ which act as vasodilatation: 1.the first way: the neprilysin(nep) activate( degradation )the ANP which convert the GTP to c GMP . 2.the second way :the nep acts ( degradation) on the BK to BK2and the BK2 NOS convert the L Arg to NO (nitrous oxide ) which also convert the GTP to c GMP with the CA++ to dilate the vessels. So the drugs which activate the neprilysin pathways cause the vasodilatation with the important roles of the NO on the genes 2. the effects of the :a. angiotensin converting enzyme inhibitors (ACEI)which decrease the breakdown of the bradykinin.b. the calcium channels blockers (CCB ) which increase the synthesis of the bradykinin . the bradykinin which binds to the b2 kinin receptors which acts as:1. on the coronary epithelium activate the intracellular NO synthase and to release the endothelium derived NO.2.on the myocardium : diffuses of the NO in the myocytes and regulates the mitochondrial respiration .But the NO in the tissues plays an important roles in the cancers because the macrophages :these cells activated by the cytokines or by the TNF which produces the nitric oxide ( NO ) which kills the organisms ( for the aids viruses also) and the malignant cells ( cancers )and the macrophages which aid and which did not aid also by the antibodies . So the most important uses of the combination from the ACEI with the CCB in the future to treat the different cancers and for the different organisms like the aids also . 4. can we use the combination also for the treatment for HT as before between the ACEI plus angiotensin II receptor blockers( ARB) to get more synergistic effects when we face the genetic mutations on the ANG gene, Ang I and Ang I receptor genes ,or on the ADDI ( adducin gene )??? . Please answer me as fast as you can .With the best regards from the dr. Antoine Sayegh The newest dr. Antoine Sayegh declarations on the cancer treatments and for the aids also : http://sayeghresearches.wetpaint.com/ My great dear: please contact me on these E-mails in the same time to confirm your sending of your e-mails to me E-mails: firstname.lastname@example.org email@example.com firstname.lastname@example.org email@example.com the websites :http//:sayeghresearches.wetpaint.com http//:antsay.webs.comwith the best regards from the dr. Antoine Sayegh The new dr. Antoine Sayegh methods for treatments from the stem cells: http://sayeghresearches.wetpaint.com/page/The+new+dr.+Antoine+Sayegh+methods+for+treatments+from+the+stem+cells%3A http://antsay.webs.com/ the aims for the treatments : 1.to use the new methods for the treatments of the chronic and for the fatal diseases also. 2.for the new hopes in the treatments for the different cancers from the killer cells( K cells ,LAK cells ), in the bone marrow suppressions ,and for the aids also from the new created of the CD4 cells . 3.to replace the harmed cells in the different tissues from the infective diseases . 4.to open the new treatments in the future for the hereditary diseases. The sources of the stem cells 1. from placenta. 2. from the adults bone marrow and from the adipose tissues . 3. from the cloning from the somatic cell nucleus transfer to the unucleated ovum as a new totipotent cells which form the blastocyte which gave us the new stem cells . 4.the methods of the dr. James Thompson : to get the pluripotent cells from the blostocyte. 5. the methods of the dr. John Gearhart :to get the stem cells from the embryonic germ cells . The methods which isolate and purify human of the different stem cells from the bone marrow or from the adipose tissues or from other sources, which use different materials for the isolation and for the culture for these cells in the different steps 1. for the processing of the bone marrow mononuclear (adipose , placental) cells. 2. for the magnetic activated cell sorting and for the fluorescence activated cells sorting also. 3.for the culture of the human monoclonal bone marrow cells. These methods use many harmful materials for the stem cells which weak its metabolic vitalities and can change its normal properties or qualities to shortening its ages and help for the deviation toward the oncogene positions ( as carcinogenic cells in the recipient tissues ) . The new dr. Antoine Sayegh methods as below: The first step :the preparing of the isolated and purified stem cells from the bone marrow: a. we take the bone marrow from the iliac crest from the human being . b. we divide the specimen into two parts : 1. we inject the first part in the blood of the animal to form against every component the antibodies the IGM and the IGG to use them later . 2. we incubate the second part (of the bone marrow ) with the animal antibodies which we got it from the first step ( the serum of the animal ) ,and in the same times we incubate the second part with the anti anti bodies the hyper variable part prepared against the anti bodies for the target cells which we need for the isolation like the CD34 or the CD38( from the known isolated cells ) to destroy all the unneeded cells and to protect the target cells . *****The preparation of the hyper variable part of the anti –antibodies from the ( known isolated target cells like CD34 ,CD38, or for ES embryonic stem cells): a. we get the antibodies against the markers proteins ( against the known makers proteins of the target cell from any person as the SSEA-3 (Stage-specific embryonic antigen) ,SEA-4,TRA-1-60(Tumor rejection antigen-1) ,TRA-1-81 or the markers of the CD34 ,CD38 ) b. we incubate part of these antibodies with the pepsin to get the Fab(ab)2 the binding antigen sites ,and the other part with the papain to get the fab(ab)1 and the fragment c (FC)to get different types of the FAB parts with the different types of the FC also in the sme times .. c. we incubate the bone marrow of the patient with the different types of the antibodies residues (held on latex) with the different suitable complements proteins to form heavy immune complexes ,we centrifuge the complexes to get from the layer of the latex the target cells . d. we isolate the target cells from the complexes from the cooling or heating , or from the changes of the ph ,so we get the weakened target cells to use them later to form from them only the anti antibodies. e. we can use instead of the latex ,the red blood cells held on its surfaces the hyper variable part of the antibodies against the different types of the FABs which act as the target antigens to form with the bone marrow of the patients with different FABs residue with complements proteins also the agglutinations forms of the immune response to collect between its nets the weakened target cells . 3. we incubate and culture the residues of the second part to get more of the target cells with its high vital activities while the other cells weakened and destroyed from the different antibodies from the uses of the STAT 3 factor and Oct-4 transcription factor which activate the LIF receptor to activate LIF –STAT 3 Signaling pathway which promotes Embryonic Stem cell self-renewal . . 4. we isolate the residues from the low speeds by the centrifuge to avoid the harms for the target cells to get the pure target cells because when these cells were cultured it gained very huge masses which precipitate it easily to the bottom of the tube. 5. we wash the cultured cells from the saline or from not harmful fluids (buffers) many times to clean it from the other ineffective attached cells. The second step: 1. we inject the patients from the vaccine( under the skin) which composed from the anti antibodies( the hyper variable parts of the antibodies ) against the target cells ( CD34,CD38 ,other cells like Embryonic Stem Cells) before many days of the uses of the stem cells ,to destroy every anti bodies against the target cells from the immune response of the uses of the stem cells.. 2. we inject the patients from the new purified stem cells with the low numbers ( not millions but hundreds thousands ) to decrease the cost( money payments) of the treatments . 3.we help the recipient tissues to receive the new stem cells with the low numbers ( hundreds thousands ) and to elongate its ages and to embrace into the defected tissues as a new normal cells from: the next third step : to confirm the new actions of the injected stem cells : a. by the injection of the angiogenesis factors into the blood of the patients , as FGFs , FGF1( the potent factors for angiogenesis ) and as FGF2 , VEGF factors also and from the TGF beta to help the stem cells to invade the recipient tissues . b. we inject into the blood of the patients also the helper the HGF and the MET which activates the proliferations of the stem cells with the E-cadherine, or from the uses of the ET-1 ( endotheline-1) which help the stem cells to be accepted from the target tissues . so the new treatments from the new methods of the isolated stem cells promise us for the best treatments for the fatal diseases in the future which act near the normal cells mechanisms to re repair the defected ( failed ) tissues or organs . with the best regards from the dr. Antoine Sayegh
Philanthropic Initiatives :
to fight against cancer and the fatal diseases
Attributes Success To:
the woks days and nights without stopping